Dual targeting of EGFR and glutaminase in lung cancer
نویسندگان
چکیده
منابع مشابه
Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation
Non-small-cell lung cancer (NSCLC) is commonly caused by a mutation in the epidermal growth factor receptor (EGFR) and subsequent aberrant EGFR signaling with uncontrolled kinase activity. A deletion mutation in EGFR exon 19 is frequently observed in EGFR gene mutations. We designed a DNAzyme to suppress the expression of mutant EGFR by cleaving the mutant EGFR mRNA. The DNAzyme (named Ex19del ...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2017
ISSN: 2372-3556
DOI: 10.1080/23723556.2017.1297883